Background & Aim: The work environment is a main contributing factor in nursing. This study investigated Iranian nurses’ attitude and point of views toward the clinical environment.
Material and Methods: In this descriptive cross sectional study a researcher-developed questionnaire was sent for a total of 1500 nurses from 20 provinces of Iran. Of these, 1160 were returned and useable for statistical analysis (response rate 77%). Sampling was simple random. Data were analyzed using description statistics.                                                                                                 
Results: The study identified several areas of challenges in the nurses work environment. In clinical care field, more than half of nurses emphasized on imperative of interdisciplinary communication (61%), making decisions autonomously in the care (57%), acting on ethical values and positive professional relationships (60%). In professional nursing tasks, the majority nurses consulted to their colleagues about caring problems (85%), delivered care based on their patients’ needs and acted on evidence-based approach (80%). Only the time devoted to the students by the nurses was neglected (37%).
 Conclusion: Work environment issues are cornerstone of health care and need to be modified to improve nursing care. These findings could be redesigning a work environment that supports nurses in providing comprehensive professional care.