Background & Aim:Occupational exposures are one of the greatest risks of transmission of blood borne diseases through blood and blood products, among health professionals. Given the importance of the issue, this study was carried aiming to determine the frequency, causes and performance of nurses, concerning occupational exposures in Hamadan.
 Materials and Methods: This study was cross-sectionally conducted. 120 of nurses working in Teaching hospitals in Hamadan were selected based on random and stratified sampling. Then the designed occupational exposures questionnaire that its validity and reliability was confirmed were handed out for completion. After data collection, data were analyzed by descriptive statistics, chi-square test and logistic regression models.
 Results: 71.7% of nurses reported occupational exposures during their service. Occupational exposure history in women and the staff with lower than 5 years work experience, was higher. About the type of exposure, most cases were related to injection or blood sampling (44%). The majority of exposures were splashing blood and secretions of patients in 39.4%. Washing and disinfectional actions after exposure, in 56.3% of cases had been done.
 Conclusion: Incidence of occupational exposures as a common risk factors for diseases transmitted through blood and blood products is common among nursing staff in Hamadan. Some bad habits such as recapping needles and not using special disposal boxes are common among nurses. Therefore, standard precautions training of personnel are essential.