Background and Objective: Currently, reproductive health and reproductive rights as part of human rights has been approved by the public. The aim of this study was to determine the knowledge and attitude of students of Lorestan University of Medical Sciences about reproductive health.
 Materials and Methods: In this cross sectional study, using a multistage random sampling method, 848 students studying in Khorramabad’s Lorestan University of Medical Sciences participated. The data was gathered through a demographic questionnaire which consisted of 19 questions in three areas of reproductive health knowledge (methods of contraception, sexual health, sexually transmitted diseases and HIV), 10 words and a question regarding the sources of information in the field of view. These were completed by the university students. The validity and reliability were confirmed by content validity and Cronbach's alpha (α = 0.96), respectively. Information were analyzed using T-test and ANOVA statistical tests.
 Results: In all of samples, 70.1% were female, 92.5% were single and had an average age of 21.2 ± 2.15 years. The average knowledge score was 42.9 ± 3.7 (from approximately 19-57 score) and the attitude was 37.7 ± 4.8 (average score 10-50), respectively. The mean scores of the attitude between age, gender, source of information and education had significant differences (P <0.034).
 Conclusion: Considering that the majority of the knowledge and attitudes of samples were not desirable, it seems that the implementation of effective educational programs on reproductive health (methods of contraception, sexual health, and sexually transmitted diseases) is necessary.