Backgrounds & Aims: Nowadays unstable angina is one of the most epidemic symptoms for coronary artery disease. Most of the patients don’t receive enough lifestyle and therapeutic interventions after cardiovascular events; hence they are faced with new events of this disease complication. This study aimed to determine the efficacy of lifestyle education on patients’ knowledge who are inflicted with unstable angina.
 Materials and Methods: This is a semi quasi experimental research which it’s population was all unstable angina inflicted patients referring to Ekbatan hospital in Hamadan. 48 patients were chosen by non- probabilistic consequential sampling. Data was collected by a questionnaire which its validation was assessed through content validity methods, it’s scientific trust through test retest. Descriptive methods a x2 and paired T-test were used to analyze research findings.
 Results: There was a significant difference between awareness in after being trained compare to pretest (p < 0.001).
 Conclusion: A simple training to change lifestyle in unstable angina inflicted patients can be very effective and suitable interaction between nurse and patient can influence the information transfer and patients’ acceptance. These primary interactions have long effect on the patients’ life. Studies show that increasing knowledge can change lifestyles.