Background & Objectives: Depression is a common illness and imposes a huge burden on different societies. In hospitals, nurses are exposed to high stress levels and this can cause depression. So the aim of this study was the investigation of the prevalence of depression and its related factors in nurses in hospitals of Khoram Abadin 2016.
 
Material and method: In this analytic-descriptive study carried out in 2016 to determine the prevalence of depression and the effective factors, 241 nurses of Khoram Abad hospital were studied by Beck’s questionnaire. After completing the questionnaires, the data were analyzed using evaluation of X2 and Kramer test.
 
Results: In this study, 50.70 percent of hospital nurses were not depressed, and the others have suffered from light depression (33.61 percent), medium depression (9.50 percent), and severe depression (4.10 percent). In this study, there was no significant change between the level of depression of nurses with chance of marriage, age, family members, standard education members and the standard parent's education.
 Conclusion: Our findings indicated that theprevalence of depression in nurses was significantly higher than the general population. Considering that nurses play an important role in improving the health of people in society, to avoid of depression the right planning is required.