Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is a serious liver disease which
convert to a challenge for health system. Various risk factors including age, sex, obesity and
diabetes are involved in the pathogenesis of this disease. The present study was conducted with the
aim of determining the epidemiological, clinical and laboratory findings of NAFLD from December
2016 to May 2017 in Khorramabad city.
Materials and Methods: In this cross-sectional study, 286 patients with NAFLD were included in
the study based on laboratory finding, clinical symptoms and sonography findings using
convenience sampling method. Demographic information, body mass index, ultrasound of NAFLD
grades and biochemical parameters (FBS, cholesterol, triglyceride, LDL, HDL, ALT and AST)
were assessed in this study. Chi-square test was used for data analysis.
Results: The average age of the patients was 49.1 ± 12.3 years. 55.2% of the study participants
were male. The BMI of the majority of these patients (49%) was between 25 and 29.9, most patients
(73.8%) had grade 1 fatty liver (mild), 21.7% had grade 2 fatty liver (moderate), and 4.5% had
grade 3 fatty liver (severe). They were in 27.3% of patients, the level of total cholesterol was ≥240
mg/dl. Also, in 55.3% of patients, the level of triglyceride was ≥200 mg/dl. In 19.6% of patients, the
level of LDL cholesterol was ≥160 mg/dl. HDL cholesterol level was below 40 mg/dl in 44.9% of
men and below 50 mg/dl in 53.1% of women. Finally, based on the measurement of fasting blood
sugar, 30.4% of the patients were pre-diabetic and 40.2% were diabetic. There was a significant
relationship between female gender (pv=0.043) and body mass index(BMI≥30)(pv<0.001) with the
severity of liver involvement.
Conclusion: NAFLD was associated with risk factors such as increasing age, male gender and
obesity, and the severity of liver involvement was associated with female gender and body mass
index. Management of disease risk factors and self-care education to patients plays a significant role
in prevention and treatment of affected patients.